Identification of an evolutionarily conserved, functional noncoding element regulated by Six1 homeoprotein
نویسندگان
چکیده
منابع مشابه
Evolutionarily Conserved Noncoding DNA
After decades of ignominy as ‘junk’, ‘parasite’ or ‘selfish’, noncoding deoxyribonucleic acid (DNA) present in introns and intergenic regions has recently been recognized as symbolizing a rich fossil record of DNA sequences subject to variation and conservation throughout evolution. In addition to clusters of evolutionarily conserved genes in close proximity to one another, human chromosomes al...
متن کاملThe Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1.
Homeobox genes constitute a large family of transcription factors that are essential during normal development and are often dysregulated in cancer. However, the molecular mechanisms by which homeobox genes influence cancer remain largely unknown. Here we show that the tissue-restricted cyclin A1 is a transcriptional target of the Six1 homeoprotein. Both genes are expressed in the embryonic but...
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The mammalian Peg3 domain harbors more than 20 evolutionarily conserved regions (ECRs) that are spread over the 250-kb genomic interval. The majority of these ECRs are marked with two histone modifications, H3K4me1 and H3K27ac, suggesting potential roles as distant regulatory elements for the transcription of the nearby imprinted genes. In the current study, the chromatin conformation capture (...
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Pi class GSTs (glutathione S-transferases) are a member of the vertebrate GST family of proteins that catalyse the conjugation of GSH to electrophilic compounds. The expression of Pi class GST genes can be induced by exposure to electrophiles. We demonstrated previously that the transcription factor Nrf 2 (NF-E2 p45-related factor 2) mediates this induction, not only in mammals, but also in fis...
متن کاملTSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOH-terminal sequence.
Antisense inactivation of the tsg101 tumor susceptibility gene in murine NIH3T3 fibroblasts leads to neoplastic transformation and tumorigenesis, which are reversed by restoration of tsg101 activity. tsg101 deficiency is associated with a series of mitosis-related abnormalities, whereas overexpression of TSG101 can also result in neoplastic transformation and the perturbation of cell cycling. T...
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ژورنال
عنوان ژورنال: Genes & Genetic Systems
سال: 2010
ISSN: 1341-7568,1880-5779
DOI: 10.1266/ggs.85.233